Examination of the SGCE gene in Tourette syndrome patients with obsessive–compulsive disorder
Identifieur interne : 003D17 ( Main/Exploration ); précédent : 003D16; suivant : 003D18Examination of the SGCE gene in Tourette syndrome patients with obsessive–compulsive disorder
Auteurs : Patricia De Carvalho Aguiar [États-Unis, Brésil] ; Melissa Fazzari [États-Unis] ; Joseph Jankovic [États-Unis] ; Laurie J. Ozelius [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2004-10.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adolescent, Adult, Female, Gene Expression (genetics), Genetic Testing, Gilles de la Tourette syndrome, Human, Humans, Male, Middle Aged, Nervous system diseases, Obsessive compulsive disorder, Obsessive-Compulsive Disorder (complications), Obsessive-Compulsive Disorder (genetics), Point Mutation (genetics), Polymerase Chain Reaction, Polymorphism, Genetic (genetics), Sarcoglycans (genetics), Tourette Syndrome (complications), Tourette Syndrome (genetics), Tourette syndrome, myoclonus–dystonia, obsessive–compulsive disorder, ϵ‐sarcoglycan.
- MESH :
- chemical , genetics : Sarcoglycans.
- complications : Obsessive-Compulsive Disorder, Tourette Syndrome.
- genetics : Gene Expression, Obsessive-Compulsive Disorder, Point Mutation, Polymorphism, Genetic, Tourette Syndrome.
- Adolescent, Adult, Female, Genetic Testing, Humans, Male, Middle Aged, Polymerase Chain Reaction.
Abstract
Mutations in the ϵ‐sarcoglycan gene (SGCE) have been reported in families with myoclonus–dystonia (M‐D). In addition to abnormal movements, obsessive–compulsive disorder (OCD) has also been described in families with M‐D. OCD is a common feature in another movement disorder, namely Tourette syndrome (TS). The comorbidity of these disorders suggests that common genetic factors might be involved in their susceptibility. To evaluate this, we performed two sets of experiments. An association study using a polymorphism within an intron of the SGCE gene was assessed in patients with TS and OCD versus controls, and the SGCE gene itself was screened for mutations in all TS/OCD patients, followed by direct sequencing of the gene in a limited number of these patients. No correlation was found by either method. © 2004 Movement Disorder Society
Url:
DOI: 10.1002/mds.20156
Affiliations:
- Brésil, États-Unis
- Texas, État de New York, État de São Paulo
- Houston, São Paulo
- Baylor College of Medicine, Université de São Paulo
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 003729
- to stream Istex, to step Curation: 003729
- to stream Istex, to step Checkpoint: 002698
- to stream PubMed, to step Corpus: 003365
- to stream PubMed, to step Curation: 003365
- to stream PubMed, to step Checkpoint: 003466
- to stream Ncbi, to step Merge: 000F23
- to stream Ncbi, to step Curation: 000F23
- to stream Ncbi, to step Checkpoint: 000F23
- to stream Main, to step Merge: 005675
- to stream PascalFrancis, to step Corpus: 002037
- to stream PascalFrancis, to step Curation: 000C84
- to stream PascalFrancis, to step Checkpoint: 002156
- to stream Main, to step Merge: 005994
- to stream Main, to step Curation: 003D17
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Examination of the SGCE gene in Tourette syndrome patients with obsessive–compulsive disorder</title><author><name sortKey="De Carvalho Aguiar, Patricia" sort="De Carvalho Aguiar, Patricia" uniqKey="De Carvalho Aguiar P" first="Patricia" last="De Carvalho Aguiar">Patricia De Carvalho Aguiar</name></author><author><name sortKey="Fazzari, Melissa" sort="Fazzari, Melissa" uniqKey="Fazzari M" first="Melissa" last="Fazzari">Melissa Fazzari</name></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Ozelius, Laurie J" sort="Ozelius, Laurie J" uniqKey="Ozelius L" first="Laurie J." last="Ozelius">Laurie J. Ozelius</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:FEEBF8116908799DA3D7A5F8D40195ACFC395A8E</idno><date when="2004" year="2004">2004</date><idno type="doi">10.1002/mds.20156</idno><idno type="url">https://api.istex.fr/document/FEEBF8116908799DA3D7A5F8D40195ACFC395A8E/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003729</idno><idno type="wicri:Area/Istex/Curation">003729</idno><idno type="wicri:Area/Istex/Checkpoint">002698</idno><idno type="wicri:doubleKey">0885-3185:2004:De Carvalho Aguiar P:examination:of:the</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:15368614</idno><idno type="wicri:Area/PubMed/Corpus">003365</idno><idno type="wicri:Area/PubMed/Curation">003365</idno><idno type="wicri:Area/PubMed/Checkpoint">003466</idno><idno type="wicri:Area/Ncbi/Merge">000F23</idno><idno type="wicri:Area/Ncbi/Curation">000F23</idno><idno type="wicri:Area/Ncbi/Checkpoint">000F23</idno><idno type="wicri:doubleKey">0885-3185:2004:De Carvalho Aguiar P:examination:of:the</idno><idno type="wicri:Area/Main/Merge">005675</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:04-0582002</idno><idno type="wicri:Area/PascalFrancis/Corpus">002037</idno><idno type="wicri:Area/PascalFrancis/Curation">000C84</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002156</idno><idno type="wicri:doubleKey">0885-3185:2004:De Carvalho Aguiar P:examination:of:the</idno><idno type="wicri:Area/Main/Merge">005994</idno><idno type="wicri:Area/Main/Curation">003D17</idno><idno type="wicri:Area/Main/Exploration">003D17</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Examination of the SGCE gene in Tourette syndrome patients with obsessive–compulsive disorder</title><author><name sortKey="De Carvalho Aguiar, Patricia" sort="De Carvalho Aguiar, Patricia" uniqKey="De Carvalho Aguiar P" first="Patricia" last="De Carvalho Aguiar">Patricia De Carvalho Aguiar</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Neurology and Neurosurgery, Federal University of São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Fazzari, Melissa" sort="Fazzari, Melissa" uniqKey="Fazzari M" first="Melissa" last="Fazzari">Melissa Fazzari</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Ozelius, Laurie J" sort="Ozelius, Laurie J" uniqKey="Ozelius L" first="Laurie J." last="Ozelius">Laurie J. Ozelius</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2004-10">2004-10</date><biblScope unit="vol">19</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1237">1237</biblScope><biblScope unit="page" to="1238">1238</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">FEEBF8116908799DA3D7A5F8D40195ACFC395A8E</idno><idno type="DOI">10.1002/mds.20156</idno><idno type="ArticleID">MDS20156</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Female</term><term>Gene Expression (genetics)</term><term>Genetic Testing</term><term>Gilles de la Tourette syndrome</term><term>Human</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Obsessive compulsive disorder</term><term>Obsessive-Compulsive Disorder (complications)</term><term>Obsessive-Compulsive Disorder (genetics)</term><term>Point Mutation (genetics)</term><term>Polymerase Chain Reaction</term><term>Polymorphism, Genetic (genetics)</term><term>Sarcoglycans (genetics)</term><term>Tourette Syndrome (complications)</term><term>Tourette Syndrome (genetics)</term><term>Tourette syndrome</term><term>myoclonus–dystonia</term><term>obsessive–compulsive disorder</term><term>ϵ‐sarcoglycan</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Sarcoglycans</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Obsessive-Compulsive Disorder</term><term>Tourette Syndrome</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Gene Expression</term><term>Obsessive-Compulsive Disorder</term><term>Point Mutation</term><term>Polymorphism, Genetic</term><term>Tourette Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Female</term><term>Genetic Testing</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymerase Chain Reaction</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Gilles de la Tourette syndrome</term><term>Homme</term><term>Obsession compulsion</term><term>Système nerveux pathologie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mutations in the ϵ‐sarcoglycan gene (SGCE) have been reported in families with myoclonus–dystonia (M‐D). In addition to abnormal movements, obsessive–compulsive disorder (OCD) has also been described in families with M‐D. OCD is a common feature in another movement disorder, namely Tourette syndrome (TS). The comorbidity of these disorders suggests that common genetic factors might be involved in their susceptibility. To evaluate this, we performed two sets of experiments. An association study using a polymorphism within an intron of the SGCE gene was assessed in patients with TS and OCD versus controls, and the SGCE gene itself was screened for mutations in all TS/OCD patients, followed by direct sequencing of the gene in a limited number of these patients. No correlation was found by either method. © 2004 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Brésil</li><li>États-Unis</li></country><region><li>Texas</li><li>État de New York</li><li>État de São Paulo</li></region><settlement><li>Houston</li><li>São Paulo</li></settlement><orgName><li>Baylor College of Medicine</li><li>Université de São Paulo</li></orgName></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="De Carvalho Aguiar, Patricia" sort="De Carvalho Aguiar, Patricia" uniqKey="De Carvalho Aguiar P" first="Patricia" last="De Carvalho Aguiar">Patricia De Carvalho Aguiar</name></region><name sortKey="Fazzari, Melissa" sort="Fazzari, Melissa" uniqKey="Fazzari M" first="Melissa" last="Fazzari">Melissa Fazzari</name><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><name sortKey="Ozelius, Laurie J" sort="Ozelius, Laurie J" uniqKey="Ozelius L" first="Laurie J." last="Ozelius">Laurie J. Ozelius</name></country><country name="Brésil"><region name="État de São Paulo"><name sortKey="De Carvalho Aguiar, Patricia" sort="De Carvalho Aguiar, Patricia" uniqKey="De Carvalho Aguiar P" first="Patricia" last="De Carvalho Aguiar">Patricia De Carvalho Aguiar</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003D17 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003D17 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:FEEBF8116908799DA3D7A5F8D40195ACFC395A8E
|texte= Examination of the SGCE gene in Tourette syndrome patients with obsessive–compulsive disorder
}}
| This area was generated with Dilib version V0.6.23. |  |